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butabarbital will lower the level or result of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Outcome of coadministering a powerful CYP3A4 inducer with fedratinib hasn't been examined.butabarbital will lessen the extent or impact of conivaptan by affecting hepatic/intestinal enzyme CYP3A4 m